In The Absence Of Truth is the band’s 2006 release, remastered by James Plotkin. The 2LP 140gr Vinyl is packaged in a tip-on gatefold jacket in two retail variants.

The album expands upon the group's previous full-length, Panopticon, further exploring lead singer Aaron Turner's clean vocals (though his former techniques, which relied more on screaming and growling, are still present as well). Musically, the album is dynamic, ranging from extended musical ambience to almost tribal drumming. ISIS continued their lengthy songwriting; In the Absence of Truth is ISIS' longest record, at almost 65 minutes.

Although the band has been defunct for over a decade, their impact on metal is still reverberating, and sales continue to make it one of Ipecac’s top artists.